(pp.279-293) E. M. Abd El-Azeem and H. M. El-mezafer ‘Ameliorative effect of M. Forsskalei grains extract on CCL4’, IJFNPH, Vol. 5, No. 4, 2012
Purpose: The aim of the present study is to evaluate the hepatoprotective effects of M. forsskalei (traditional use in Saudi Arabia). Many herbs have been used as natural remedies for the prevention and/or treatment of liver diseases. Various herbs and herbal products are believed to have liver protective functions and are widely used in clinical practice.
Design/methodology/approach: CCl4 continues to provide an important model substance to elucidate the mechanisms of action of hepatotoxic and oxidative stress effects. Rats were pretreated with aqueous extracts of the grains of M. forsskalei.
Findings: Pretreatment of rats with aqueous extract of the grains of M. forsskalei in multiple doses (50 and 100 mg/kg b.w. for 60 days) significantly prevented the CCl4 induced hepatic damage as indicated by the serum marker enzymes (AST, ALT and LDH). It also prevented CCl4-induced oxidative stress in the rats’ liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzyme (SOD) and glutathione.
Originality/value: Our results suggest that M. forsskalei effectively prevents liver injury, mainly through down regulation of oxidative stress.
Keywords: M. forsskalei; Hepatoprotective; Lipid profile; Oxidative stress